Set in Quebec at the turn of the 19th to 20th century, The Heart Specialist is the epic story of Agnes White, a lonely orphaned girl fascinated by the "wrong" things—microscopes, dissections, and anatomy instead of more ladylike interests—who rises to the status of one of the world's most celebrated pioneering women doctors. Not only does she break through patriarchal academic barriers; she masters the science of the human heart, becoming a scholar of international fame, all in a place and time inimical to intelligent women.